I dont hear too many people running for President talking about these things, other than Yang, and this concerns me. 1) Miniaturization technology combined with DNA editing becoming ubiquitous will allow for massive destruction of human life by virtually anyone that has the resources and will to do it. We have to find ways to peacefully integrate all ethnicity's, religions and ideologies so that they will resolve differences peacefully instead of going to suicide bomber mode. How do we do this? 2) Space mining is going to be the New World of the mid 21st century, and that is not scifi folks. The immense wealth in Near Earth Asteroids is in the thousands of trillions of dollars and that is less than 10% of the total asteroid mass in our solar system. 16 Psyche is just mind bogglingly loaded. We need to try to iron out rules and appeals, etc to avoid conflict triggering events and not tank our commodities market. 3) Strong AI and the Singularity is definitely coming people. Strap in and hold on to your ass cause its going to be a thrill a minute. 4) Androids will be ubiquitous by 2050. Everyone will own at least two. How will that change our culture, our economy? Our family structures? Where will the government get revenue from with almost $0 from individuals tax funds? 5) I think the odds are very high that we will openly encounter extra terrestrial intelligence. How will this affect our religions, our self image and our sense of security?